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(Increase in growth hormone receptor expression in tendon fibroblasts)

However, as the development and testing of remyelination-based therapies requires effective model systems with sustained demyelination and lack of complete endogenous remyelination, we conclude that 1 mM CPZ treatment of brain slice cultures is not a viable ex vivo model for these studies, however, could prove to be useful in acute demyelination studies, pending further characterization

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In addition, Sirt1 induces mitophagy through the deacetylation and activation of the mitophagy proteins, including PINK1, PARKIN, and LC3 [37, 39]