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Boschung-Pasquier L, Atkinson A, Kastner LK, et al

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IGF-1 inhibits MPTP/MPP(+)-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER

Aggregation occurs when individual peptide molecules clump together into insoluble complexes, typically triggered by temperature fluctuations, mechanical agitation, or freeze-thaw cycles