glutathione persister cells cancer

glutathione persister cells cancer peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis - Liu - 2021 - Clinical and Translational Medicine Redox signaling-governed drug-tolerant persister cancer

Name: glutathione persister cells cancer peroxidase 4‐dependent glutathione high‐consumption drives acquired platinum chemoresistance in lung cancer‐derived brain metastasis - Liu - 2021 - Clinical and Translational Medicine Redox signaling-governed drug-tolerant persister cancer
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Redox signaling governed drug tolerant persister cancer cell: a key spark of treatment failure Signal Transduction and Targeted Therapy Utilizing glutathione triggered nanoparticles to enhance chemotherapy of lung cancer by reprograming the tumor microenvironment ScienceDirect Drug tolerant persister cancer cells are vulnerable to GPX4 inhibition Nature Tolerant Persister Cancer Cells and the Path to Resistance to Targeted Therapy Involvement of glutathione peroxidases in the occurrence and development of breast cancers Journal of Translational Medicine Springer Nature Link

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As a result, the flavonoids decreased cytotoxicity in cells and mitigated the decrease of glucose-stimulated insulin production due to inhibiting the nitric oxide synthase (NOS) gene expression

Free radicals are normally produced in the body due to the influence of external factors, such as pollution, cigarette smoke, or internal, due to intracellular metabolism when antioxidant mechanisms are exceeded