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prkn / // Sod2 +/+ and Sod2 // prkn +/+ mice were crossed to generate prkn // Sod2 offspring, which was interbred to produce the desired prkn / // Sod2 (bi-genic) mouse

Failure to account for environmental exposures may explain the lack of consistency

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Abbreviations CO: Carbon monoxide DNA: Deoxyribonucleic acid GPx: Glutathione peroxidase GSH: Reduced glutathione GSSeH: Glutathioselenol GSSeSG: Selenodiglutathione H 2 O 2 : Hydrogen peroxide H 2 S: Hydrogen sulfide (gas) H 2 Se: Hydrogen selenide (gas) HS - : Hydrosulfide anion HSe - : Hydroselenide anion IL: Interleukin LDL: Low-density lipoprotein LPS: Lipopolysaccharide mRNA: Messenger ribonucleic acid Msr: Methionine sulfoxide reductase NaHSe: Sodium hydrogen selenide NF-B: Nuclear factor kappa B NO: Nitric oxide NTIS: Non-thyroidal illness syndrome ROS: Reactive oxygen species Se: Selenium SCL: Selenocysteine -lyase SeO 3 2- : Selenite SeO 4 2- : Selenate T3: Triiodothyronine T4: Thyroxine TNF-: Tumour necrosis factor alpha tRNA: Transfer ribonucleic acid Trx: Thioredoxin TrxR: Thioredoxin reductase TSH: Thyroid stimulating hormone References National Research Council (1983) Selenium in nutrition: Revised Edition

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