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Butyrate and Heart Failure HF is a condition in which the hearts ability to fill or evacuate blood is compromised ( In a recent study by Mollar et al., butyrate was negatively associated with area under the concentration curve (AUC-H2) in patients with HF, implying that butyrate is lower in patients with higher exhaled hydrogen test (small intestinal bacterial overgrowth (SIBO), the results of the aforementioned study suggest that dysbiosis followed by reduced levels of butyrate could play a role in the pathology of HF ( in vivo and in vitro experiments show that butyrate exerts histological cardio-protective effects