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PubMed Gharavi AG, Diamond JA, Smith DA, Phillips RA

Moreover, approximately one-third of patients exhibit treatment-resistant depression (TRD) and fail to respond to existing pharmacotherapies, while some patients, particularly children and adolescents, may experience spontaneous improvement even without treatment (Richardson et al., 2025

CrossRef Basic Research Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes Praise Chanmee Kim, Ji Seon Lee, Sung Soo Chung, Kyong Soo Park Diabetes Metab J