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Without enough B12, hair follicles can struggle to work effectively

[4] [22] Serious but rare adverse effects require immediate medical attention and include: Pancreatitis : Severe abdominal pain radiating to the back, with or without vomiting Gallbladder disease : Right upper quadrant pain, particularly after meals Acute kidney injury : Usually secondary to severe dehydration from gastrointestinal symptoms Severe allergic reactions : Rash, difficulty breathing, or swelling of face, lips, or throat Patients should contact their healthcare provider if they experience persistent vomiting, severe abdominal pain, signs of dehydration, or any concerning symptoms

Since these guidelines are preliminary, researchers should conduct initial dose-finding studies to identify the optimal range for their specific models

Glia 56 , 5058 (2008)

[39] The elderly are at increased risk because they tend to produce less stomach acid as they age, a condition known as achlorhydria, thereby increasing their probability of B 12 deficiency due to reduced absorption