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Atp7b / mice recapitulate the main features of WD including accumulation of copper in the liver and extensive liver damage, which manifest in hepatitis, fibrosis, and the formation of cholangiocarcinoma 32

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A study demonstrated that alterations in phosphatidylcholine (PC) metabolism in ARDS patients correlated with increased inflammation and oxidative stress, 50 resulting in more severe lung injury and lower levels of surfactant PC species, which contribute to alveolar collapse and heightened inflammation 51 (Figure 2)