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B Vitamins in Heart Failure It is now well accepted that patients with HF present micronutrient deficiencies owing to malabsorption resulting from splanchnic congestion, increased urinary loss of nutrients caused by diuretics largely used in HF treatment, as well as a poor oral intake at advanced stages of HF [146,147,148]

Research has examined glutathione and its precursor N-acetyl cysteine (NAC) and found clinical benefit in treating peripheral artery disease 2 , Parkinsons disease 3 , fatty liver 4 , coronary reperfusion injury 5 , bipolar disorder 6-7 obsessive compulsive disorder 8 , schizophrenia 6,9,10 , addiction treatment 11-12 , autism 13 and flu prevention 14

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Furthermore, the fraction of oral vitamin C that is not absorbed passes into the large intestine where it draws in water and can cause loose stools the familiar gastrointestinal side effect of high-dose oral supplementation