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Arch Biochem Biophys 671:203209 Xiao M, Lu D, Tian J, Yu Y, Zhang Q, Zhang L, Chang D (2020) Protective effects of GLP-1 receptor agonist lixisenatide on oxygen-glucose deprivation/reperfusion-induced endothelial injury

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According to research, while promoting the closure of pancreatic-cell KATP channels to boost insulin secretion, this medicine may also lead to the closure of cardiac KATP channels, resulting in a higher cardiac risk in those people (138, 139)

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Recombinant CYP1A2 and CYP3A4 including a microsomal formulation containing cytochrome b 5 and cytochrome P450 reductase, drug-metabolizing cytochromes P450, interacted with wild-type PGRMC1, but not with the Y113F mutant, in a haem-dependent manner (Fig

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