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Numerous studies have strongly supported the role of ALA in treating diabetic neuropathy

Maintaining sufficient glutathione stores protects hepatocytes from oxidative stress and supports efficient detoxification

Glutathione is a powerful antioxidant naturally produced in the body, composed of three amino acidsglutamine, glycine, and cysteine[1]

Importantly, ferroptosis is inherently pro-inflammatory, establishing a self-amplifying pathogenic axis that operates across major cardiovascular diseases

In general, glycolytic metabolites upstream of GAPDH were enriched upon high dose VitC treatment, while those downstream were depleted, in line with an inhibition of GAPDH by VitC, ultimately leading to the disruption of glycolysis and TCA cycle also observed in several proteomics studies (Table 4, Fig