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Specific allergic manifestations consisting of swelling of eyelids, lips, pharynx and larynx, urticaria, asthma, and bronchospasm, sometimes with a concomitant fall in blood pressure

Responsible interpretation requires acknowledging both the strong mechanistic research and the current lack of large-scale human clinical trials for systemic uses

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For comparison, semaglutide alone achieved approximately 14.9% in the STEP 1 trial, and tirzepatide achieved approximately 20.9% in SURMOUNT-1 at 72 weeks