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The treatment group exhibited fewer adverse events than the placebo group

For example, in a preclinical study, curcumin was found to reduce levels of heat shock protein 27 (HSP27) and P-glycoprotein (P-gp), causing an increase in the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5-fluorouracil (5-FU), which led to enhanced cell death in 5-FU-resistant HCT-8 cancer cells (He et al

Hezaveh K, Shinde RS, Klotgen A, Halaby MJ, Lamorte S, Ciudad MT, et al

The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

This suggests that NAC at these doses is well tolerated and likely safe for further studies