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A pharmacokinetics study published in Frontiers in Pharmacology found an average intravenous elimination half-life (t1/2) of 15.2 minutes in rats, with the intramuscular peak plasma concentration reached at 3 minutes post-injection

This may lead to damage building up on the skin

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To the contrary, for the reasons stated in the proposed rule (89 FR 61853), we continue to believe that the specific subpopulations of Medicare beneficiaries who are otherwise eligible for assignment to an entity participating in a disease- or condition-specific CMS Innovation Center model, but who may not be captured by 425.402(e)(2)(ii)(D) because their models consider primary care services for purposes of assignment, could benefit from the focused attention and increased care coordination offered by an entity participating in a disease- or condition-specific model

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