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Epilepsia 48 , 801805 (2007)

Activated CD8 + T cells were fixed and observed by transmission electron microscopy ( B )

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Thus, not only PGC 1 upregulation is paralleled by an improvement in insulin sensitivity, but also PGC 1-dependent defects in mitochondrial oxidative metabolism are reversible confirming this transcription cofactor as a valuable target to restore insulin sensitivity and the aberrant transcriptional control of mitochondrial biogenesis (Mootha et al., 2003