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10.1007/s00125-019-05029-y Diabetologia 152 Scheibye-KnudsenM.MitchellS

Sequence: N/A (Small Molecule)

The main search terms included: environmental carcinogens, industrial chemicals, pesticides, persistent organic pollutants, heavy metals, airborne contaminants, endocrine disruptors, food-derived toxins, tumorigenesis, and cancer risk. These combinations were adapted to each databases indexing system to ensure comprehensive retrieval

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Paradoxically, endogenous SAM accumulation or exogenous SAM treatment inhibits CRC proliferation, induces apoptosis (178, 179), and reverses promoter hypomethylation of oncogenes such as c-Myc and Ras (180)