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It means that a significant portion of the orally administered 5-Amino-1MQ might not actually reach systemic circulation in its active form, or at least not at the desired concentration

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These so called cutoffs are derived from serum MMA concentrations compiled from US NHANES 20032006 data in which the central 95% reference intervals (2.5th to 97.5th percentile) for serum MMA concentrations were presented (Pfeiffer et al., 2013)