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Red Blood Cell Production : Vitamin B12 helps prevent anemia by supporting red blood cell formation, ensuring adequate oxygen delivery to tissues

Human research is limited, though animal data is robust and consistent across multiple models

Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990

Scoring system: + denotes limited performance or early-stage evidence, ++ denotes moderate performance, and +++ denotes strong performance or translational evidence

It appears to promote angiogenesis (new blood vessel formation) at injury sites, upregulate growth factor receptors, and modulate nitric oxide signaling