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Summary Cytosolic redox balance is tightly coupled to aspartate synthesis through the malate-aspartate shuttle, and limiting the malate-aspartate shuttle has been proposed to constrain tumor growth by restricting aspartate availability

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The Federal Tribunal therefore limited itself in controlling that the CAS Panel followed the procedure provided for in the IWF Anti-Doping Rules (the Appellant had the burden to rebut the presumption based on the standard of a balance of probabilities) of the violation of the anti-doping rules, which he failed to do in the case at hand (4A_80/2017 at 6.3)

This effect was efficiently reverted by IGF-1 administration [161]

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