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Neurotransmitter binding to receptors Neurotransmitters function by binding to receptors on the cell membrane of the neuron releasing the neurotransmitter (i.e., presynaptic neuron) or to receptors on the cell membrane of the receiving cell (i.e., the postsynaptic neuron)

Today the situation is more straightforward

The aggressiveness of Cu + destroys the lysosomal membrane with release of Cu + to cytoplasm and consequent hepatocellular injury, furthermore the plasma membrane becomes leaky with loss of Cu + to blood and eventually destruction of erythrocyte membranes (hemolysis)

In the first case, the inability to hydroxylate lysine residues precludes normal intermolecular cross-linking of collagen trimers, and in the second instance, absence of procollagen peptidase prevents normal proteolytic cleavage of the NH 2 -terminus of procollagen chains

This cascade ultimately leads to renal fibrosis, marked by myofibroblast proliferation, excessive extracellular matrix deposition, glomerulosclerosis, tubular atrophy, and microvascular rarefaction, resulting in irreversible nephron loss and a decline in renal function toward end-stage renal disease