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Int J Clin Pharmacol Res 1992;12:299-304

However, in CRC, FXR expression is often downregulated, and lower FXR levels are associated with poorer clinical outcomes (Sun et al., 2021

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These findings have also been described for MDD, e.g., in a large meta-analysis by Bot and Milaneschi et al., which found an association between depression risk and different lipid classes [14] and in several other studies, as reviewed in detail by Guerreiro Costa et al

Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012