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Snapshot Proponents May help cleanse the bowels before medical procedures May relieve constipation Skeptics Most health claims are not backed by science The benefits from coffees active compounds are more effectively (and pleasantly) achieved by drinking it Used as part of fraudulent and expensive cancer therapies May cause digestive issues, bowel injuries, and electrolyte imbalances Use through History The first documented uses of coffee enemas for poisoning and post-operative care date back to the 19th century

Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium

This strategy aimed to overcome first-pass hepatic metabolism and limited BBB penetration 126

This property along with tissue/tumor expression of GT was used to develop -glutamyl prodrugs

Adjamian P, Hall DA, Palmer AR, Allan TW, Langers DR