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The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition

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204 Although Gadd45a has been linked to the global DNA methylation and transcriptional regulation, Gadd45a loss does not change the global DNA methylation pattern in our experimental setting, 204 indicating that manipulation of the Gadd45a gene could delay organ ageing, and prolong the health span and life span of premature ageing mice