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Neurotrophic and anti-inflammatory effects (days to weeks) Semax elevates BDNF within hours, but the downstream effects of that elevation, including new synaptic connections, improved neurotransmitter signaling, and reduced inflammatory gene expression, unfold over days and weeks

Phenotypes on demand via switchable target protein degradation in multicellular organisms

Seminal publications predating the search window were included if they provided foundational mechanistic, pharmacological, or historical context that was not superseded by subsequent work

A 2- to 3-fold overdose from recommended doses can result in collapse or death of the animal due to circulatory or respiratory depression (Rector et al, 1996

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