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The Growth Hormone-Sleep Axis# The relationship between GH and sleep is one of the best-characterized hormone-sleep interactions in endocrinology: Approximately 75% of daily GH secretion occurs during sleep, with the largest pulse occurring within the first 90 minutes of sleep onset during the initial slow-wave sleep period Growth hormone-releasing hormone (GHRH) itself promotes slow-wave sleep when administered to healthy subjects GH decline with aging parallels the decline in slow-wave sleep, suggesting a shared regulatory mechanism Cortisol, which antagonizes GH release, reaches its nadir during early sleep, creating a permissive window for GH secretion This bidirectional relationship means that peptides enhancing GH release may indirectly support deep sleep, while peptides improving sleep architecture may enhance the natural GH pulse

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