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for example, a randomized trial found that splitting the dose resulted in a decrease of less than 1% in hematocrit over 3 months, while more substantial reductions required further dose lowering or temporary suspension of therapy(Okano et al., 2025)

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When using a modifier is appropriate, refer to the Medicaid National Correct Coding Initiative (NCCI) web page of the Centers for Medicare & Medicaid Services (CMS) website for specific guidance on the proper use of modifiers

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