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In DCs, glutathione plays a critical role in maintaining REDOX homeostasis and protecting DCs from oxidative stress, lack of glutathione inhibits DCs maturation and the subsequent production of pro-inflammatory cytokines (69)

Phospholipase C is an enzyme necessary for the transduction of photoperiodic signals and is activated via melatonin receptors

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Biochemical and histological studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels), cell proliferation (evidenced by reduction of skin hyperplasia and suppression of PKC/JNK/Jun pathway), and inflammation (evidenced by reduction of ICAM-1/VCAM-1 expression, NF-B binding activity, and nuclear p65/p50 levels)