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In monotherapy trials with semaglutide oral tablets for T2DM, severe hypoglycemia (requiring the assistance of another person) was reported in 1% of patients receiving the 7 mg tablets and 0% of patients receiving the 14 mg tablets or placebo

Up to 80% of male PD individuals have been indeed found to suffer from erectile dysfunction [191], highlighting a major, though often unspoken, therapeutic need in these individuals

Pregnancy and Breastfeeding: B12 needs increase during these times, and injections can be beneficial

Interest in longevity & health span : people want not only more years, but better years

Chronic joint/tendon issues: 68 weeks may be appropriate