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Regulatory bodies, such as the US-FDA and the European Medicines Agency (EMA), play pivotal roles in scrutinizing the safety profile of any drugs, nanomaterials, including AuNPs [311]

DTT treatment increases rips-1 transcript abundance We next used qRT-PCR to assess the gene expression changes after exposure of synchronised wild-type N2 L4s to 5 mM DTT for 24 h, conditions we found to have a minimal effect on worm development within this time frame

Local TH activation is crucial for UCP1 expression and consequently adaptive thermogenesis, and its impairment despite normal serum TH levels could suggest reduced thermogenic capacity or function under prolonged stress [29, 30]

10.2147/DDDT.S419361 23 AtiaG