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Description

Although there is a broad clinical spectrum of glutathione synthetase deficiency, manifestations usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs (eg, respiratory distress, sepsis, hyperbilirubinemia) (62

Table 1 Summary of cardiovascular effects and clinical considerations for antiretroviral therapy (ART) drug classes

Hayashi, K., Yoshida, K

doi: 10.3389/fncel.2019.00212

This nuanced understanding also speaks to the metabolic flexibility of immune cells and further highlights the need to continue to define compensatory metabolic responses engaged upon primary pathway inhibition or blockade