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These genes control mitochondrial iron, tRNA transport, and ubiquitination ( HSPA1-A, -B , and -L genes , responsible for heat-shock protein 70, a key player in the mitochondrial unfolded protein response ( Similarly, mitophagy genes such as PARK7 and LRKK2 are linked to UC and CD, respectively (65)

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Similar content being viewed by others Introduction Site-specific protein phosphorylation is one of the most important post-translational modifications (PTMs) as it can rapidly modulate a proteins function by changing its activity, subcellular localization, interactions, or stability 1