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Both melphalan and chlorambucil are larger molecules than most of the compounds studied in this work, and they possess aromatic rings in their chains, which increases their hydrophobicity

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Although the results for probing depth and gingival recession were not statistically significant, the single injection group demonstrated a significant therapeutic effect in improving bone defect depth (P = 0.0083)an outcome that is challenging to achieve with current non-surgical clinical treatments (Supplementary Table 11)

After planning the treatment, preparation is followed