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While the addition of merely 0.25 mM ATP to wild-type -syn monomers was adequate to begin the induction of fibril aggregation in a dose-dependent manner

Therefore, drug therapy targeting macrophages may be an appropriate treatment for CP pancreatic fibrosis

390,391,392 Thus, rosiglitazone has anti-inflammatory effect by decreasing levels of NFB and inhibiting the A42 production in mice, is considering as therapeutic agent for AD

Griffith, O.W., Biologic and pharmacologic regulation of mammalian glutathione synthesis

Interestingly, the connection between FH and mTOR seems mutual: kidney-specific Tsc1 loss, which leads to constitutive mTOR activation, causes an mTOR-dependent downregulation of FH and the accumulation of fumarate, promoting renal epithelial transformation [85]