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Description

Many EDCs mediate their effects by binding with high affinity to the aryl hydrocarbon receptor (AhR), an orphan nuclear receptor that is expressed throughout the female and male reproductive tracts and by cells of the immune system (Hernandez-Ochoa et al., 2009

Our laboratory utilizes a developmental toxicant exposure model created by exposing pregnant C57/BL6 mice (F0, or founding generation) to a single 10 g/kg dose of TCDD by oral gavage on embryonic day 15.5 providing in utero and lactational exposures of TCDD to offspring (F1 generation) (Nayyar et al., 2007)