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For example, HA and IR have been shown to trigger ferroptosis in the pregnant uterus and placental tissue ( 4 Gut microbiota: a potential regulatory hub for ferroptosis in PCOS 4.1 Gut microbiota dysbiosis and host iron metabolism dysregulation The gut microbiota comprises symbiotic microorganisms that colonize the human intestinal tract and interact with the ovaries through microbial metabolites, immune signaling, and neuroendocrine pathways

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BOMSS guidance further specifies monitoring responsibilities: specialist multidisciplinary team (MDT) follow-up is recommended for at least two years after surgery, with lifelong monitoring thereafter, typically in primary care

LPS translocation through a leaky gut generates systemic low-grade inflammation that crosses the blood-brain barrier and activates microglial inflammatory responses a mechanism implicated in depression, anxiety, and potentially Alzheimers disease