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For example, a typical enzyme inducer such as phenobarbitone will induce groups CYP1A, 2A, 2B and 3A, whereas alcohol is known to induce CYP2E1 The induction of an enzyme may result in also the inactivation or detoxification of an active of toxic substance or, in opposition, in the production of an active or toxic metabolite from an inactive precursor.( Sweenyet al., 2006) Drug-drug interactions have become an important issue in health care