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(2023) proposed twelve hallmarks of aging: genomic instability, telomere shortening, epigenetic alterations, impaired protein homeostasis, defective autophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and microbial imbalance

Its interest stems from pre-clinical research showing tissue-repair, anti-inflammatory, cytoprotective and angiogenic effects in animal models

Its inhibition at the tissue level without systemic suppression represents a pharmacologically favorable profile for research applications where inflammation is driving local tissue damage

Foods rich in sulfur compounds, selenium, and Vitamin C also support glutathione synthesis