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Developed by Novo Nordisk, this long-acting amylin analogue works by activating amylin receptors throughout the body, particularly in areas that regulate appetite and digestive function [1]

37,38 In some MDD patients, stress leads to long-term elevated glucocorticoids, resulting in synaptic structural changes and remodeling, and the stress-induced hyperactivity of the HPA axis leads to negative feedback imbalance of the HPA axis, which is also related to depression

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doi: 10.1021/acs.jmedchem.7b00389

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