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Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1

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Furthermore, both EMPA and MET significantly reduced TGF expression ( P = 0.0141 and P = 0.0039, respectively), but the difference between the two was not significant ( P = 0.0847) (Figures 7F,H)

Electroporation-mediated IGF-1 gene transfer to the hindlimbs of these animals did not alter myofiber size and muscle mass [166]