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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

Email: [email protected] ORCID: Affiliation: 16 Centro de Investigacin Biomdica en Red Enfermedades Neurodegenerativas (CiberNed), National Institute of Health Carlos iii, 28031 Madrid, Spain 17 Departament de Biochemistry and Molecular Biomedicine, University of Barcelona, 08028 Barcelona, Spain 18 Institut de Qumica Terica i Computacional (IQTCUB), School of Chemistry, University of Barcelona, 08028 Barcelona, Spain These authors contributed equally to this work

Totally 1044 patients from 39 hospitals who underwent curative HCC resection were recruited and randomized in 2:1 ratio to receive either Huaier Granule or no additional treatment for up to 96 weeks