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The activities of manganese superoxide dismutase and glutathione-S-transferase, which detoxify superoxide and other electrophilic substances, respectively, are also inhibited by nitration (203, 346)

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Together, they create a sustained and balanced increase in circulating GH and IGF-1 levels

Parallel evolutionary pathways for glutathione transferases: structure and mechanisms of the mitochondrial class Kappa rGSTK1-1

Hypoxic tumor microenvironment activates GLI2 via HIF-1 and TGF-2 to promote chemoresistance in colorectal cancer