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In our translational work, we also reported a link between LAC levels, cellular aging and metabolic function in the antidepressant responses to the insulin-sensitizing agent pioglitazone, an agent for treatment of diabetes type 2 and tested as potential antidepressant [60]

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In brief, cells were seeded in 24well plates at a density of 1.5 10 4 cells/well and treated with dimethyl sulfoxide (DMSO) or 100 M PFOS for 24 h with or without pretreatment with 10 mM l-Carnitine for 24 h

Take 2 capsules a day at least 30 minutes before a meal