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In reality, constipation incidence is significantly higher even in depression patients not receiving pharmacological treatment than in healthy controls (Mawe and Hoffman, 2013)

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GeroScience (2023)

Morphine inhibits DMV Ach neuronal activity to induce constipation To elucidate whether morphine-induced DMV Ach neuronal hypoactivity contributes to constipation, we investigated the changes in neuronal activity within the DMV Ach small intestine circuit by infusing FG into the small intestinal wall of C57 mice (Supplementary Fig