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Similarly to astrocytes, activated microglia release excessive glutamate through gap junction hemichannels (Takeuchi et al., 2006) and their importance in glutamate excitotoxicity were described by Umebayashi and co-authors, as the blockade of these channels by INI-0602 was protective in secondary spinal cord injury (Umebayashi et al., 2014)

Figure 31: Photograph of Professor Bernard Thorens, credit Center for Integrative Genomics, University of Lausanne

Hochhaus, B

Although UPA was temporarily discontinued, research on uterine fibroids continues