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This finding supports the idea that the mutation in pad2-1 close to the glutamate conjugating residues of GSH1 might influence the affinity of the enzyme for BSO, as it was proposed for cad2-1 54,71

In addition, native remnant lipoproteins can induce foam cell formation via a number of apoE receptors (LRP1 and VLDLR) (Figure 2) (50,51)

Age-related macular degeneration: economic burden and value-based medicine analysis

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Consistent with our findings, pharmacological inhibition of MAT2A with FIDAS-5 has been reported to reduce MAT2A expression, suppress glycolytic metabolism, and impair tumor growth both in vitro and in vivo in multiple myeloma and osteosarcoma models 17,18