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Exploring the targets and molecular mechanisms of thalidomide in the treatment of ulcerative colitis: network pharmacology and experimental validation

Medicine (Baltimore) 99(2):e18560 Vermeulen J, Coene PP, Van Hout NM, van der Harst E, Gosselink MP, Mannaerts GH et al (2009) Restoration of bowel continuity after surgery for acute perforated diverticulitis: should Hartmanns procedure be considered a one-stage procedure

Studies have shown that B cells also play a role in the progression of osteoarthritis (OA), as their proliferation and differentiation capabilities are altered in the synovium of OA patients ( Research indicates that B cells can secrete various pro-inflammatory factors, including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-), which induce chondrocyte death and cartilage matrix destruction (126) ( Figure 4 )

Atomistic molecular dynamics simulations consisting of 1-palmitoyl-2-linoleoyl- sn -glycero-3-phosphatidylcholine (PLPC) and its peroxidation and aldehyde products 16 were reported to show that defects occurred with both aldehyde and peroxide lipids, but full pore formation only occurred for aldehyde lipids

Fracture repair: general aspects and influence of osteoporosis and anti-osteoporosis treatment