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The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K

The sub-compartmental organization of redoxstasis, based on spatially constrained protein relays (Woo et al., 2010), and the low diffusibility of small redox active compounds such as H 2 O 2 (Bienert and Chaumont, Cysteines and Diseases Secretory Proteins Owing to the importance of structural and regulatory disulfide bonds in membrane and secretory proteins, mutations in luminal cysteines generally have dramatic consequences

As a primary m 5 C writer, NSUN2 plays a central role in orchestrating eukaryotic translation rates [175, 180]

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