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In parallel, AGE can reverse neuronal loss in the CA1 and CA2 regions of the hippocampus, increase the activity of antioxidant enzymes, including SOD and glutathione peroxidase (GP), as well as decrease the malondialdehyde (MDA) level in the A-exposed rat brain homogenate

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Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

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In rare cases, the injections may cause allergic reactions