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Patients who completed SIBO treatment and cleared the bacterial overgrowth but are still symptomatic because the underlying mucosal damage was never addressed

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

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Cell- and tissue-based studies have explored a proposed mechanism involving upregulation of beta-3 adrenergic receptor signaling, and knockout-model work has been used to probe the receptor dependence of the observed metabolic responses

Particular attention to BPC-157 dosing if the patient is using NSAIDs for analgesia