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doi:10.1021/bc0100713 192

Mechanistic themes seen in preclinical research In animal and mechanistic work, AOD-9604 has been associated with: Increased lipolysis (breaking down stored fat) Reduced lipogenesis (reducing fat storage) Interactions with -adrenergic pathways in adipose tissue have been discussed as part of its lipolytic signaling profile (OUP Academic) In obese animal models, AOD-9604 has shown reductions in body weight and body fat and changes consistent with increased fat mobilization

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Application of JA mitigated the adverse effects of alkaline stress and caused significant TSSs accumulation of 2.22 and 12.73% in 100 mM Na 2 CO 3 + 10 M JA and 150 mM Na 2 CO 3 + 10 M JA treatments, respectively, compared to only alkaline stressed plants with 100 and 150 mM 10 M JA + 0 mM Na 2 CO 3 , respectively (Table 1)